SYSTEMATIC EXPRESSION ANALYSIS OF LIGAND-RECEPTOR PAIRS REVEALS IMPORTANT CELL-TO-CELL INTERACTIONS INSIDE GLIOMA

Systematic expression analysis of ligand-receptor pairs reveals important cell-to-cell interactions inside glioma

Abstract Background Glioma is the most commonly diagnosed malignant and aggressive brain cancer in adults.Traditional researches mainly explored the expression profile of glioma at cell-population level, but ignored the heterogeneity and curlimal hedgehog interactions of among glioma cells.Methods Here, we firstly analyzed the single-cell RNA-seq (

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Undrained stability of braced excavations in clay considering the nonstationary random field of undrained shear strength

Abstract The basal heave stability of supported excavations is an essential problem in geotechnical engineering.This paper considers the probabilistic analysis of basal heave stability of supported excavations anti social social club neon sign with spatially random soils by employing the random adaptive finite element limit analysis and Monte Carlo

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The role of astrocytes in Multiple Sclerosis progression

Multiple sclerosis is an inflammatory disorder causing central nervous system demyelination and axonal injury.Although its etiology remains elusive, several lines of evidence support the concept that autoimmunity plays a major role in disease pathogenesis.The course ofMS is highly variable; nevertheless, the majority of patients initially present a

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